No job is more stressful, dangerous or exhilarating than those of the Firefighters, Rescue Squad and Paramedics of Chicago Firehouse 51. These are the courageous men and women who forge headfirst into danger when everyone else is running the other way. But the enormous responsibilities of the job also take a personal toll. With big reputations and hefty egos, the pressure to perform and make split-second decisions is bound to put squad members at odds. When a tragedy claims one of their own, there's plenty of guilt and blame to go around. When it's "go-time" though, they put their differences aside and everything on the line for each other. From renowned Emmy-winning producer Dick Wolf.

A house fire leads members of the truck and squad to race to save the lives of the couple trapped inside, and then are faced with the perplexing aftermath. Meanwhile, Chief Boden (Eamonn Walker) prepares to start his new family, while the combination of life at work and home pushes Casey (Jesse Spencer) and Dawson (Monica Raymund) apart. Elsewhere Molly’s II has its chance to shine at the Chicago Holiday Fest.

The firehouse receives unsettling news when two of their own come up missing following a routine call, prompting members of Chicago P.D. to lead the search. Meanwhile, Casey (Jesse Spencer) and Dawson (Monica Raymund) have a hard time figuring how to juggle their personal and professional lives. Elsewhere, Chief Boden (Eamonn Walker) and Donna struggle with news that their newborn has potential complications and they receive a surprise out-of-town visitor.

Severide (Taylor Kinney) and Dawson (Monica Raymund) discover startling evidence found at a storage unit fire that appears connected to the fire that took Shay’s life. Meanwhile, the firehouse bands together when Chaplain Orlovsky (guest star Gordon Clapp) is the victim of a bad car accident. Elsewhere, Chief Boden’s (Eamonn Walker) father (guest star Richard Roundtree) visits, but quickly wears out his welcome with his unsolicited parenting advice.

More clues surface surrounding the fire that killed Shay, leading Severide (Taylor Kinney) to a most unexpected source who may be able to provide pertinent information. Meanwhile, Shay’s sister Megan (guest star Ellen Woglom) comes to town, prompting members of the firehouse to remember Shay’s life. Elsewhere, Cruz (Joe Minoso) is in for a surprise when Otis’s (Yuri Sardarov) grandmother moves into their apartment, while Boden finds a way to help his dying father (guest star Richard Roundtree) make the most of his last few weeks.

Firehouse 51 is called to the scene of a harrowing and challenging disaster

When the team responds to a semi-truck leaking hydrochloric acid in a busy intersection, Casey (Jesse Spencer) and Dawson (Monica Raymund) find their relationship being put to the test. Meanwhile, Severide (Taylor Kinney) learns more about Brittany’s (guest star Serinda Swan) past and Mouch (Christian Stolte) has some difficulties in his dating life.

Casey (Jesse Spencer) comes to the aid of his sister Christie (guest star Nicole Forester) and faces down his corrupt brother-in-law, while Brett (Kara Kilmer) goes above and beyond for a mother in need. Elsewhere, Mills (Charlie Barnett) gets educated on the exciting world of unlicensed private investigation and Dawson (Monica Raymond) begins training with Herrmann (David Eigenberg).